Keywords
shear-wave elastography (SWE)
cellular technologies
denervation-reinnervation processes
gunshot injury
muscle stiffness
How to Cite
Abstract
Objective. The purpose of this article is to determine the feasibility of using shear-wave elastography (SWE) in assessing the influence of cell technologies on denervation-reinnevaration processes in the muscles of gunshot injury.
Material and Methods. Ultrasound examination and elastography were performed on a GE Healthcare LOGIQ P9 device with a 5-12 MHz multi-frequency probe. 19 injured males aged 35-57 (average age 45.31±0.95 years) with denervation-reinnervation processes in muscles due to gunshot damage were examined. The examination was performed on the affected limb and on the contralateral healthy limb. Statistical processing was performed using Microsoft Excel and StatSoft Inc. STATISTICA.
Results: 11 patients with lesions of the radial nerve on the upper limb and 8 people of the peroneal nerve on the lower leg were included in the study. With lesions of the radial nerve, we examined m. extensor digitorum on the forearm. For lesions of the peroneal nerve, m. tibialis anterior of the lower leg was chosen. After the examination, all patients underwent the procedure of injecting BMAC (Bone Marrow Aspirate Concentrate) into the target muscle. Control studies of shear wave elastography were performed again one month after the procedure. The obtained statistical data on the state of muscle stiffness in dynamics allow us to conclude about the reliably positive outcome of the treatment.
Conclusions. Ultrasound of muscles with shear wave elastography is a reliable and innovative method of obtaining information about the state of muscle stiffness when assessing the influence of cellular technologies on denervation-reinnervation processes in patients after gunshot injuries.
References
Paramalingam S, Needham M, Bulsara M, Mastaglia FL, Keen HI. The longitudinal study of muscle changes with ultrasound: Differential changes in idiopathic inflammatory myopathy subgroups [published online ahead of print, 2023 May 24]. Rheumatology (Oxford). 2023;kead239. doi:10.1093/ rheumatology/kead239
Hernández-Socorro CR, Saavedra P, López-Fernández JC, Ruiz-Santana S. Assessment of Muscle Wasting in LongStay ICU Patients Using a New Ultrasound Protocol. Nutrients. 2018;10(12):1849. Published 2018 Dec 1. doi:10.3390/ nu10121849
Kim GB, Seo MS, Park WT, Lee GW. Bone Marrow Aspirate Concentrate: Its Uses in Osteoarthritis. Int J Mol Sci. 2020;21(9):3224. Published 2020 May 2. doi:10.3390/ ijms21093224
Lysak A, Savosko S, Strafun S, Utko N, Makarenko O. Effect of bone marrow aspirate in denervation-induced skeletal muscle atrophy. Wiad Lek. 2022;75(3):634-640.
Gaiovych I, Savosko S, Labunets I, Utko N, Makarenko A, Chaikovsky Y. Sciatic nerve regeneration after autografting and application of the bone marrow aspirate concentration. Georgian Med News. 2019;(295):145-152.
Xiang Y, Dai J, Xu L, Li X, Jiang J, Xu J. Research progress in immune 2021;287:120117. doi:10.1016/j.lfs.2021.120117
Study of bone marrow aspirate injection effect on denervated muscle according to electromyography studies Eureka:Health sciences – T6 – №30. – 2020 – С.40-47
Nenadic I, Urban M, Greenleaf JF et al (2019) Ultrasound elastography for biomedical applications and medicine, 1st edn. Wiley, Hoboken, NJ.
Zúñiga LDO, López CAG, González ER. Ultrasound Elastography in the Assessment of the Stiffness of Spastic Muscles: A Systematic Review. Ultrasound Med Biol. 2021;47(6):14481464. doi:10.1016/j.ultrasmedbio.2021.01.031
Ryu J, Jeong WK. Current status of musculoskeletal application of shear wave elastography. Ultrasonography. 2017;36(3):185-197. doi:10.14366/usg.16053
Snoj Ž, Wu CH, Taljanovic MS, Dumić-Čule I, Drakonaki EE, Klauser AS. Ultrasound Elastography in Musculoskeletal Radiology: Past, Present, and Future. Semin Musculoskelet Radiol. 2020;24(2):156-166. doi:10.1055/s-0039-3402746
Zúñiga LDO, López CAG, González ER. Ultrasound Elastography in the Assessment of the Stiffness of Spastic Muscles: A Systematic Review. Ultrasound Med Biol. 2021;47(6):14481464. doi:10.1016/j.ultrasmedbio.2021.01.031
Miller T, Ying M, Sau Lan Tsang C, Huang M, Pang MYC. Reliability and Validity of Ultrasound Elastography for Evaluating Muscle Stiffness in Neurological Populations: A Systematic Review and Meta-Analysis. Phys Ther. 2021;101(1):pzaa188. doi:10.1093/ptj/pzaa188
Liu J, Pan H, Bao Y, Zhao Y, Huang L, Zhan W. The Value of Real-Time Shear Wave Elastography before and after Rehabilitation of Upper Limb Spasm in Stroke Patients. Biomed Res Int. 2020;2020:6472456. Published 2020 Aug 18. doi:10.1155/2020/6472456
Leng Y, Wang Z, Bian R, et al. Alterations of Elastic Property of Spastic Muscle With Its Joint Resistance Evaluated From Shear Wave Elastography and Biomechanical Model. Front Neurol. 2019;10:736. Published 2019 Jul 10. doi:10.3389/fneur.2019.00736
Gao J, He W, Du LJ, et al. Quantitative Ultrasound Imaging to Assess the Biceps Brachii Muscle in Chronic Post-Stroke Spasticity: Preliminary Observation. Ultrasound Med Biol. 2018;44(9):1931-1940. doi:10.1016/j.ultrasmedbio.2017.12.012
Lee SSM, Jakubowski KL, Spear SC, Rymer WZ. Muscle material properties in passive and active stroke-impaired muscle. J Biomech. 2019;83:197-204. doi:10.1016/j.jbiomech.2018.11.043
Analan PD, Ozdemir H (2020) Assessment of poststroke biceps brachialis muscle stiffness by shear-wave elastography: a pilot study. Muscle Ligaments Tendons J 10:531.
Aşkın A, Kalaycı ÖT, Bayram KB, et al. Strain sonoelastographic evaluation of biceps muscle intrinsic stiffness after botulinum toxin-A injection. Top Stroke Rehabil. 2017;24(1):12-17. doi:10.1080/10749357.2016.1183865
Cosgrove D, Piscaglia F, Bamber J, et al. EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 2: Clinical applications. Ultraschall Med. 2013;34(3):238-253. doi:10.1055/s-0033-1335375
Vo MH, Lin CJ, Chieh HF, et al. Behavior of medial gastrocnemius muscle beneath kinesio taping during isometric contraction and badminton lunge performance after fatigue induction. Sci Rep. 2023;13(1):1779. Published 2023 Jan 31. doi:10.1038/s41598-023-28818-3
Xu GX, Chen PY, Jiang X, Huang CC. Visualization of Human Skeletal Muscle Mechanical Anisotropy by Using Dual-Direction Shear Wave Imaging. IEEE Trans Biomed Eng. 2022;69(9):2745-2754. doi:10.1109/TBME.2022.3152896
Giambini H, An KN. Ultrasound Elastography for Hand Soft Tissue Assessment. Hand Clin. 2022;38(1):119-128. doi:10.1016/j.hcl.2021.08.013
Vuorenmaa AS, Siitama EMK, Mäkelä KS. Inter-operator and inter-device reproducibility of shear wave elastography in healthy muscle tissues. J Appl Clin Med Phys. 2022;23(9):e13717. doi:10.1002/acm2.13717
Romer C, Czupajllo J, Zessin E, Fischer T, Wolfarth B, Lerchbaumer MH. Stiffness of Muscles and Tendons of the Lower Limb of Professional and Semiprofessional Athletes Using Shear Wave Elastography. J Ultrasound Med. 2022;41(12):3061-3068. doi:10.1002/jum.16062
Lall PS, Alsubiheen AM, Aldaihan MM, Lee H. Differences in Medial and Lateral Gastrocnemius Stiffness after ExerciseInduced Muscle Fatigue. Int J Environ Res Public Health. 2022;19(21):13891. Published 2022 Oct 26. doi:10.3390/ ijerph192113891.
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