Stromal Vascular Fraction of Adipose Tissue: Prospects for Use in the Treatment of Osteoarthritis and Articular Cartilage Injuries (Literature Review)
No. 4(123) (2024), Reviews
No. 4(123) (2024)

Stromal Vascular Fraction of Adipose Tissue: Prospects for Use in the Treatment of Osteoarthritis and Articular Cartilage Injuries (Literature Review)

Reviews
https://doi.org/10.37647/2786-7595-2024-123-4-47-51
Published February 3, 2025
O.O. Kostrub
SI “Institute of Traumatology and Orthopedics of NAMS of Ukraine”, Kyiv, Ukraine
P.V. Didukh
SI “Institute of Traumatology and Orthopedics of NAMS of Ukraine”, Kyiv, Ukraine
R.O. Serhiienko
SI “Institute of Traumatology and Orthopedics of NAMS of Ukraine”, Kyiv, Ukraine
R.I. Blonskyi
SI “Institute of Traumatology and Orthopedics of NAMS of Ukraine”, Kyiv, Ukraine
I.A. Zasadniuk
SI “Institute of Traumatology and Orthopedics of NAMS of Ukraine”, Kyiv, Ukraine
S.P. Chornobai
SI “Institute of Traumatology and Orthopedics of NAMS of Ukraine”, Kyiv, Ukraine
V.A. Podik
SI “Institute of Traumatology and Orthopedics of NAMS of Ukraine”, Kyiv, Ukraine
ARTICLE PDF (Українська)

Keywords

stromal vascular fraction
mesenchymal stem cells
osteoarthritis
cartilage

How to Cite

Kostrub, O., Didukh, P., Serhiienko, R., Blonskyi, R., Zasadniuk, I., Chornobai, S., & Podik, V. (2025). Stromal Vascular Fraction of Adipose Tissue: Prospects for Use in the Treatment of Osteoarthritis and Articular Cartilage Injuries (Literature Review). TERRA ORTHOPAEDICA, (4(123), 47-51. https://doi.org/10.37647/2786-7595-2024-123-4-47-51
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver

Download Citation

Endnote/Zotero/Mendeley (RIS) BibTeX

Abstract

Summary. Osteoarthritis (OA) is a chronic, progressive, degenerative-dystrophic joint disease primarily caused by damage to the articular cartilage. Conservative pharmacological treatment of OA consists of prescribing nonsteroidal anti-inflammatory drugs, chondroprotectors, hyaluronic acid injections, and therapeutic blockades with glucocorticosteroids. The use of orthobiological agents represents an alternative method in OA treatment. Among the variety of orthobiological approaches, adipose tissue serves as a new and attractive source of stem cells for the treatment of OA. The stromal vascular fraction creates an environment where stem cells can interact and stimulate regeneration.

https://doi.org/10.37647/2786-7595-2024-123-4-47-51
ARTICLE PDF (Українська)

References

Dhillon MS, Behera P, Patel S, Shetty V. Orthobiologics and platelet rich plasma. Indian J Orthop. 2014;48(1):1-9. doi: 10.4103/0019-5413.125477.

Purita J, Lana JFSD, Kolber M, Rodrigues BL, Mosaner T, Santos GS, et al. Bone marrow-derived products: A classification proposal - bone marrow aspirate, bone marrow aspirate concentrate or hybrid? World J Stem Cells. 2020;12(4):241-250. doi: 10.4252/wjsc.v12.i4.241.

Huddleston HP, Maheshwer B, Wong SE, Chahla J, Cole BJ, Yanke AB. An Update on the Use of Orthobiologics: Use of Biologics for Osteoarthritis. Oper Tech Sports Med. 2020;28:150759. doi:10.1016/j.otsm.2020.150759.

Han S, Sun HM, Hwang KC, Kim SW. Adipose-Derived Stromal Vascular Fraction Cells: Update on Clinical Utility and Efficacy. Crit Rev Eukaryot Gene Expr. 2015;25(2):145-52. doi: 10.1615/critreveukaryotgeneexpr.2015013057.

Guo J, Nguyen A, Banyard DA, Fadavi D, Toranto JD, Wirth GA, et al. Stromal vascular fraction: A regenerative reality? Part 2: Mechanisms of regenerative action. J Plast Reconstr Aesthet Surg. 2016;69(2):180-8. doi: 10.1016/j.bjps.2015.10.014.

Dykstra JA, Facile T, Patrick RJ, Francis KR, Milanovich S, Weimer JM, et al. Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose-Derived Stromal Vascular Fraction. Stem Cells Transl Med. 2017;6(4):1096-1108. doi: 10.1002/sctm.16-0337.

Nguyen A, Guo J, Banyard DA, Fadavi D, Toranto JD, Wirth GA, et al. Stromal vascular fraction: A regenerative reality? Part 1: Current concepts and review of the literature. J Plast Reconstr Aesthet Surg. 2016;69(2):170-9. doi: 10.1016/j.bjps.2015.10.015.

Lana JFSD, Lana AVSD, da Fonseca LF, Coelho MA, Marques GG, Mosaner T, et al. Stromal Vascular Fraction for Knee Osteoarthritis - An Update. J Stem Cells Regen Med. 2022;18(1):11-20. doi: 10.46582/jsrm.1801003.

Boquest AC, Noer A, Collas P. Epigenetic programming of mesenchymal stem cells from human adipose tissue. Stem Cell Rev. 2006;2(4):319-29. doi: 10.1007/BF02698059.

Huang T, He D, Kleiner G, Kuluz J. Neuron-like differentiation of adipose-derived stem cells from infant piglets in vitro. J Spinal Cord Med. 2007;30 Suppl 1(Suppl 1):35-40. doi: 10.1080/10790268.2007.11753967.

Kern S, Eichler H, Stoeve J, Klüter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells. 2006;24(5):1294-301. doi: 10.1634/stemcells.2005-0342.

Kunze KN, Burnett RA, Wright-Chisem J, Frank RM, Chahla J. Adipose-Derived Mesenchymal Stem Cell Treatments and Available Formulations. Curr Rev Musculoskelet Med. 2020;13(3):264-280. doi: 10.1007/s12178-020-09624-0.

Rodbell M. Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J Biol Chem. 1964;239:375-80.

Vodyanik MA, Yu J, Zhang X, Tian S, Stewart R, Thomson JA, et al. A mesoderm-derived precursor for mesenchymal stem and endothelial cells. Cell Stem Cell. 2010;7(6):718-29. doi: 10.1016/j.stem.2010.11.011.

Krampera M, Franchini M, Pizzolo G, Aprili G. Mesenchymal stem cells: from biology to clinical use. Blood Transfus. 2007;5(3):120-9. doi: 10.2450/2007.0029-07.

Bisicchia S, Bernardi G, Pagnotta SM, Tudisco C. Micro-fragmented stromal-vascular fraction plus microfractures provides better clinical results than microfractures alone in symptomatic focal chondral lesions of the knee. Knee Surg Sports Traumatol Arthrosc. 2020;28(6):1876-1884. doi: 10.1007/s00167-019-05621-0.

Dimarino AM, Caplan AI, Bonfield TL. Mesenchymal stem cells in tissue repair. Front Immunol. 2013;4:201. doi: 10.3389/fimmu.2013.00201.

Blaber SP, Webster RA, Hill CJ, Breen EJ, Kuah D, Vesey G, et al. Analysis of in vitro secretion profiles from adipose-derived cell populations. J Transl Med. 2012;10:172. doi: 10.1186/1479-5876-10-172.

Chazenbalk G, Bertolotto C, Heneidi S, Jumabay M, Trivax B, Aronowitz J, et al. Novel pathway of adipogenesis through cross-talk between adipose tissue macrophages, adipose stem cells and adipocytes: evidence of cell plasticity. PLoS One. 2011;6(3):e17834. doi: 10.1371/journal.pone.0017834.

Traktuev DO, Prater DN, Merfeld-Clauss S, Sanjeevaiah AR, Saadatzadeh MR, Murphy M, et al. Robust functional vascular network formation in vivo by cooperation of adipose progenitor and endothelial cells. Circ Res. 2009;104(12):1410-20. doi: 10.1161/CIRCRESAHA.108.190926.

Koh YJ, Koh BI, Kim H, Joo HJ, Jin HK, Jeon J, et al. Stromal vascular fraction from adipose tissue forms profound vascular network through the dynamic reassembly of blood endothelial cells. Arterioscler Thromb Vasc Biol. 2011;31(5):1141-50. doi: 10.1161/ATVBAHA.110.218206.

Kwon HM, Hur SM, Park KY, Kim CK, Kim YM, Kim HS, et al. Multiple paracrine factors secreted by mesenchymal stem cells contribute to angiogenesis. Vascul Pharmacol. 2014;63(1):19-28. doi: 10.1016/j.vph.2014.06.004.

Zhu M, Dong Z, Gao J, Liao Y, Xue J, Yuan Y, et al. Adipocyte regeneration after free fat transplantation: promotion by stromal vascular fraction cells. Cell Transplant. 2015;24(1):49-62. doi: 10.3727/096368913X675133..

Fu S, Luan J, Xin M, Wang Q, Xiao R, Gao Y. Fate of adipose-derived stromal vascular fraction cells after co-implantation with fat grafts: evidence of cell survival and differentiation in ischemic adipose tissue. Plast Reconstr Surg. 2013;132(2):363-373. doi: 10.1097/PRS.0b013e31829588b3.

Eto H, Ishimine H, Kinoshita K, Watanabe-Susaki K, Kato H, Doi K, et al. Characterization of human adipose tissue-resident hematopoietic cell populations reveals a novel macrophage subpopulation with CD34 expression and mesenchymal multipotency. Stem Cells Dev. 2013;22(6):985-97. doi: 10.1089/scd.2012.0442.

Zeyda M, Farmer D, Todoric J, Aszmann O, Speiser M, Györi G, et al. Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production. Int J Obes (Lond). 2007;31(9):1420-8. doi: 10.1038/sj.ijo.0803632.

Tiemessen MM, Jagger AL, Evans HG, van Herwijnen MJ, John S, Taams LS. CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc Natl Acad Sci U S A. 2007;104(49):19446-51. doi: 10.1073/pnas.0706832104.

Yu L, Yang F, Zhang F, Guo D, Li L, Wang X, et al. CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production. Cell Death Dis. 2018;9(9):905. doi: 10.1038/s41419-018-0927-9.

Semon JA, Zhang X, Pandey AC, Alandete SM, Maness C, Zhang S, et al. Administration of murine stromal vascular fraction ameliorates chronic experimental autoimmune encephalomyelitis. Stem Cells Transl Med. 2013;2(10):789-96. doi: 10.5966/sctm.2013-0032.

Premaratne GU, Ma LP, Fujita M, Lin X, Bollano E, Fu M. Stromal vascular fraction transplantation as an alternative therapy for ischemic heart failure: anti-inflammatory role. J Cardiothorac Surg. 2011;6:43. doi: 10.1186/1749-8090-6-43.

Biazzo A, D'Ambrosi R, Masia F, Izzo V, Verde F. Autologous adipose stem cell therapy for knee osteoarthritis: where are we now? Phys Sportsmed. 2020;48(4):392-399. doi: 10.1080/00913847.2020.1758001.

Anil U, Markus DH, Hurley ET, Manjunath AK, Alaia MJ, Campbell KA, et al. The efficacy of intra-articular injections in the treatment of knee osteoarthritis: A network meta-analysis of randomized controlled trials. Knee. 2021;32:173-182. doi: 10.1016/j.knee.2021.08.008.

Jayaram P, Ikpeama U, Rothenberg JB, Malanga GA. Bone Marrow-Derived and Adipose-Derived Mesenchymal Stem Cell Therapy in Primary Knee Osteoarthritis: A Narrative Review. PM R. 2019;11(2):177-191. doi: 10.1016/j.pmrj.2018.06.019.

Panchal J, Malanga G, Sheinkop M. Safety and Efficacy of Percutaneous Injection of Lipogems Micro-Fractured Adipose Tissue for Osteoarthritic Knees. Am J Orthop (Belle Mead NJ). 2018;47(11). doi: 10.12788/ajo.2018.0098.

Azzini GOM, Santos GS, Visoni SBC, Azzini VOM, Santos RGD, Huber SC, et al. Metabolic syndrome and subchondral bone alterations: The rise of osteoarthritis - A review. J Clin Orthop Trauma. 2020;11(Suppl 5):S849-S855. doi: 10.1016/j.jcot.2020.06.021.

Nishimura S, Manabe I, Nagai R. Adipose tissue inflammation in obesity and metabolic syndrome. Discov Med. 2009;8(41):55-60.

Philipsen A, Hansen AL, Jørgensen ME, Brage S, Carstensen B, Sandbaek A, et al. Associations of objectively measured physical activity and abdominal fat distribution. Med Sci Sports Exerc. 2015;47(5):983-9. doi: 10.1249/MSS.0000000000000504.

Boada-Pladellorens A, Avellanet M, Pages-Bolibar E, Veiga A. Stromal vascular fraction therapy for knee osteoarthritis: a systematic review. Ther Adv Musculoskelet Dis. 2022;14:1759720X221117879. doi: 10.1177/1759720X221117879.

Comella K, Parlo M, Daly R, Depasquale V, Edgerton E, Mallory P, et al. Safety Analysis of Autologous Stem Cell Therapy in a Variety of Degenerative Diseases and Injuries Using the Stromal Vascular Fraction. J Clin Med Res. 2017;9(11):935-942. doi: 10.14740/jocmr3187w.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Most read articles by the same author(s)