Keywords
arthrosis
fibrosis of the joint capsule
How to Cite
Abstract
Introduction. Minimally invasive animal models of joint damage enable the study of the key pathogenetic mechanisms of shoulder arthrosis and the identification of dominant factors that influence the development of structural disorders in the most common forms of slowly progressive human arthrosis.
Objective. This study aims to determine the relationship between morphological signs of damage to the articular cartilage of the shoulder joint and its capsule in an experimental model of enzymatic joint damage.
Materials and Methods. In a rabbit model of enzymatic joint injury, changes in the morphology of the capsule and articular surfaces of the shoulder joint were examined 4 months after the injection of collagenase.
Results. Collagenase injection into the shoulder joint caused damage to the cartilage and synovial membrane, followed by changes in capsule density and an increase in its thickness. A strong positive correlation was found between changes in the synovial membrane and the intensity of cellular inflammatory infiltration, as well as between synovial membrane condition and degeneration of articular cartilage. Remodeling of the fibrous matrix of connective tissue initiates fibrotic changes in the shoulder joint capsule.
Conclusions. Omarthrosis progression factors create a closed vicious circle of structural shoulder joint disorders, reinforcing each other. This circle can only be broken surgically by performing a selective capsulotomy of the shoulder joint.
References
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