The Role of Vitamin D Metabolite Deficiency in the Development of Structural and Functional Disorders in Coxarthrosis
ARTICLE PDF (Українська)

Keywords

coxarthrosis; structural and functional disorders; deficiency of vitamin D metabolites.

How to Cite

Kalashnikov, O., Gayko, G., Burianov, O., Tymochuk, V., & Poluliakh, D. (2021). The Role of Vitamin D Metabolite Deficiency in the Development of Structural and Functional Disorders in Coxarthrosis. TERRA ORTHOPAEDICA, (1(108), 49-55. https://doi.org/10.37647/0132-2486-2021-108-1-49-55

Abstract

Summary. At present, there is a need to systematize the data of our own comprehensive research and literature in order to determine the role of active metabolites of vitamin D in the formation of structural and functional disorders (SFD) in osteoarthritis of the hip.

Objective: on the basis of our own complex researches and data of literature, to determine the role of the insufficiency of vitamin D metabolites in the development of SFD in coxarthrosis.

Materials and Methods. The basis for determining the role of active metabolites of vitamin D in the development of SFN in coxarthrosis was our own comprehensive studies of 506 patients with osteoarthritis of the hip and data from the literature.

Results. On the basis of the theory of functional systems, a conceptual model for the development of SFD in coxarthrosis has been developed. The leading factor in the development of SFD in the rapid progression of idiopathic and dysplastic osteoarthritis of the hip is the lack of active metabolites of vitamin D. The presence of undifferentiated connective tissue dysplasia in turn causes a decrease in the absorption of provitamin D in the stomach and intestines. With a slow progression of idiopathic coxarthrosis, the leading factor in the development of these disorders is the excessive load on the hip joint. Factors of violation of biomechanical conditions and injury of the hip joint are factors of the progression of coxarthrosis of dysplastic and post-traumatic genesis. Pathogenic factors lead to functional and structural changes in systems of different levels and their elements with the development of inverted processes in the structures of the hip joint.

Conclusions. Insufficiency of vitamin D metabolites on the background of undifferentiated connective tissue dysplasia leads to biochemical changes in articular cartilage and serum, affects both osteo- and chondrogenesis, leads to reduced immune status of patients and the development of clinical manifestations of rapid progression of idiopathic and dysplastic coxarthrosis. With a slow progression of idiopathic coxarthrosis, the main factor leading to the development of the above mentioned disorders is the excessive load on the hip joint. Factors of violation of biomechanical conditions and injury of the hip joint determine the development of SFD in coxarthrosis of dysplastic and post-traumatic genesis.

https://doi.org/10.37647/0132-2486-2021-108-1-49-55
ARTICLE PDF (Українська)

References

Kabalyk M.A. Prevalence of osteoarthritis in Russia: regional aspects of trends in statistical parameters during 2011–2016. Rheumatology Science and Practice. 2018;56(4):416–422 [in Russian].

Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care & Research. 2020;72 (2):220-233. DOI: 10.1002/acr.24131.

Bannuru RR, Osani MC, Vaysbrot EE, Arden NK, Benne K, Bierma-Zeinstraet SMA, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis and Cartilage. 2019:27(11):1578-1589. DOI: 10.1016/j.joca.2019.06.011.

Vannabouathong C, Bhandari M, Bedi A, Khanna V, Yung P, Shetty V, et al. Nonoperative Treatments for Knee Osteoarthritis: An Evaluation of Treatment Characteristics and the Intra-Articular Placebo Effect: A Systematic Review. JBJS Reviews. 2018;6(7):e5. DOI: 10.2106/ JBJS.RVW.17.00167.

Martel-Pelletier J , Barr AJ, Cicuttini FM, Conaghan PG, Cooper C, Goldring MB, et al. Osteoarthritis. Nat Rev Dis Primers. 2016;(2):16072. DOI: 10.1038/nrdp.2016.72.

Simenach BI, Snisarenko PI, Baburkina OP. Arthritic deformity syndrome caused by hereditary predisposition. Clinical features. Ortoped., travmatol. y protezyr. 2004;(3):95-100. [in Ukrainian].

Schilt M. Optimal age for hip sonography screenining. Ultrashall med. 2001;22(1):39-47. DOI:10.1055/s-2001-11249.

Kadurina TI. Hereditary collagenopathies (clinic, diagnostics, treatment and clinical examination). SPb.: Nevskiy Dialekt; 2000. 271 s. [in Russian].

Zemtsovskiy EV. S Connective tissue dysplasia of the heart. SPb.: OOO “Politeks-Nord-Vest”; 2000. 155 s. [in Russian].

Kovalenko VN, Bortkevich OP. Osteoarthritis: A Practical Guide. K: Morion; 2003. 448 s. [in Russian].

Korzh NA, Dedukh NV, Zupanets IA. Osteoarthritis: Conservative Therapy. Kharkov: Zolotye stranitsy; 2007. 424 s.

Haiko HV, Kalashnikov OV. Hip osteoarthritis: factors of origin and progression, treatment and prevention. Naukovyi zhurnal MOZ Ukrainy. 2014;5(1):70-77. [in Ukrainian].

Mukhametov FF, Mukhametov UF. Principles of choosing the swivel component of the hip joint endoprosthesis. Vserossiyskiy monotematicheskiy sbornik nauchnykh statey “Endoprotezirovanie v Rossii”. 2009;(5):69-75. [in Russian].

Gao X.R., Chen Y.S., Deng W.The effect of vitamin D supplementation on knee osteoarthritis: A meta-analysis of randomized controlled trials. Int J Surg. 2017;46:14–20. DOI: 10.1016/j.ijsu.2017.08.010

Sylvia VL, Del Toro F, Dean DD, Hardin RR, Schwartz Z, Boyan BD. Effects of 1 alpha, 25 (OH)2D3 on rat growth zone chondrocytes are mediated via cyclooxygenase-1 and phospholipase A(2). J. Cell. Biochem. 2001;36:32-45. DOI: 10.1002/jcb.1072.

van Leeuwen JP, van den Bemd GJ, Driel M, Buurman CJ, Pols H. 24, 25-dihydroxyvitamin D3 and bone metabolism. Steroids. 2001;66(3-5):375-380. DOI: 10.1016/s0039-128x(00)00155-0.

Gromova OA, Torshin IYu, Zakharova IN, Malyavskaya SI. The role of vitamin D in the regulation of immunity, prevention and treatment of infectious diseases in children. Meditsinskiy sovet. 2017;(19):52-60. DOI: 10.21518/2079-701x-2017-19-52-60.

Maylyan EA, Reznichenko NA, Maylyan DE. The role of vitamin D in the regulation of anti-infectious immunity. Krymskiy zhurnal eksperimentalnoy i klinicheskoy meditsiny. 2016;6(4):75-82. [in Russian].

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